NIH R01 · 2024
Role of p21 positive senescent cells in radiation-induced skeletal injury and repair
Project Summary/Abstract Skeletal deterioration and related fracture risk is exacerbated in the elderly cancer survivors receiving radiation treatment (RTx), affecting independent living, and reducing quality of life. Cellular senescence, one of the major pathways induced following RTx-induced DNA damage, is characterized by a pro-inflammatory senescence associated secretory phenotype (SASP, consisting of chemokines, cytokines, growth factors, matrix degrading enzyme, etc), and is mainly regulated by cyclin dependent kinase inhibitors (CDKi’s) p16Ink4a and p21Cip1. Till recently, it was understood that p16Ink4a and p21Cip1 co-expressed in all senescent cells and regulated their function…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.