NIH R01 · 2025
Mitochondrial Metabolism and Cancer
PROJECT SUMMARY/ABSTRACT Transformation of normal cells to cancer cells involves complex changes influenced by oncogenes, inactivation of tumor suppressors, and disrupted signaling pathways, imposing a metabolic demand that is sustained through alterations in critical metabolic pathways and the availability of nutrients in the tumor microenvironment to support tumor expansion. Previously, we have shown that the electron transport chain (ETC) is necessary for in vivo tumor initiation and progression. However, the exact reasons behind the crucial role of the ETC in tumor growth remain somewhat unclear. We hypothesize the ETC supports tumor growth by maintaining oxidative tricarboxylic acid…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.