NIH R01 · 2024
Investigation of Pallidal Neurons in Motor Inhibition
Project Summary The long-term goal of this project is to deepen our understanding of how the external globus pallidus (GPe) within the basal ganglia controls movement and how it goes awry in Parkinson’s disease (PD). Despite compelling evidence that the GPe plays a critical role in regulating motor activity, its neuronal composition has been poorly defined. As the neurons that encompass the GPe are heterogeneous, understanding how the activity of the GPe is regulated in behavioral and disease contexts has posed a challenge. Through a series of investigations during the last funding cycle, we surveyed the molecular landscape of the mouse GPe. By characterizing a number of driver and reporter…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.