NIH R01 · 2025
Cholinergic Dysfunction in Glaucoma
Although intraocular pressure (IOP) is the only clinically modifiable risk factor for glaucoma, the exact role of IOP elevation in glaucomatous neurodegeneration is unclear, as the cause of glaucoma remains unknown. Even worse, glaucoma may progress in patients under controlled IOP, indicating that additional factors are pivotal to its pathogenesis. A critical barrier to progress in investigating glaucoma mechanisms is the limited comprehensive, quantitative, and non-invasive approaches for detecting and predicting the involvement of the entire visual system during glaucoma development. We recently developed these needed approaches using magnetic resonance imaging (MRI) and spectroscopy…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.