NIH R01 · 2025
Prospective Study of the Gut Microbiome in Aging
PROJECT SUMMARY / ABSTRACT Emerging data suggest that aging is associated with changes in the gut microbiome, including reduction in microbial diversity, variation in specific taxa, and alterations in microbial-derived metabolites. Gut microbial alterations have also been linked to age-related diseases such as dementia, physical disability, cardiovascular disease (CVD), cancer, obesity, and diabetes mellitus, potentially through mechanisms that include modulation of inflammation and intestinal permeability. This background supports our overarching hypothesis that the gut microbiome modulates the association between aging, diet, lifestyle, and geriatric outcomes of dementia, disability,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.