NIH R01 · 2025
pH-Dependent Switching of ESX-1 Substrates in Mycobacterial Pathogenesis
PROJECT SUMMARY Pathogenic mycobacteria, including Mycobacterium tuberculosis, cause acute and chronic infections that significantly im- pact human health. Mycobacterium marinum is a non-tubercular mycobacterial pathogen and a well-established model for studying several aspects of M. tuberculosis pathogenesis, including ESX-1 secretion. Early during infection, pathogenic mycobacteria reside in and adapt to the phagosome. The pH of mycobacterial phagosomes differs based on the immunolog- ical activation state of macrophages. Although mycobacteria escape the phagosome using the ESX-1 secretion system, the mechanisms used by ESX-1 to lyse phagosomes under conditions of varied pH is a major gap…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.