NIH R01 · 2025
Self Assembled Peptide Nanoparticles as Multi-Antigen Universal Influenza Vaccines
The goal of this proposal is to use self-assembled protein nanocages (SAPNs) as a universal flu vaccine platform and evaluate and enhance vaccine effectiveness. Despite vaccines, seasonal influenza viruses have continuously caused annual widespread disease and deadly flu pandemics occasionally arise. The limited success in preventative flu vaccines is due in large part to frequent reassortment and mutation of genes to generate different influenza strains. To address this, highly conserved regions of viral proteins are desirable targets for subunit vaccines. However, conserved antigens alone are usually poorly immunogenic. Vaccine nanoparticles can enhance immunogenicity via multivalency,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.