NIH R01 · 2025
Regulation of ceramide-1-phosphate metabolism in cell signaling networks
Metabolic reprogramming (MR) is an important cellular mechanism in response to cell stress & agonist-induced proliferation/polarization, which is characterized by the suppression of oxidative phosphorylation (OXPHOS) & subsequent upregulation of aerobic glycolysis, lipid metabolism, mitochondrial fission, and the oxidative pentose phosphate pathway (PPP). The key signals that regulate and induce MR are currently unclear, but our laboratory found that ceramide-1-phosphate (C1P), a bioactive sphingolipid produced by the phosphorylation of ceramide by ceramide kinase (CERK), was required for this type of MR & for the induction of oxidative DE-phosphorylation (dePhos), a novel ATP-backflow…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.