NIH R01 · 2024
Determining role of 14-3-3zeta in IL-17A signaling
Summary Interleukin-17 (IL-17), a pro-inflammatory cytokine, is pathogenic in autoimmune diseases such as Inflammatory Arthritis (IA). IA affects more than 1% of the worldwide population and remains incurable to date1. Ectopic IL17A expression in mice induces IA phenotype and provides a model to study mechanisms2. Activation of IL-17A receptor (IL-17R) recruits a signaling complex consisting of Act1 and TRAFs (Tumor Necrosis Factor Receptor Associated Factors). Activation of TRAF6 or TRAF2/5 results in transcriptional (IL6) and post- transcriptional (CXCL1) outcomes of IL-17A cytokine. TRAFs often interact with each other and influence signaling outcomes. The crosstalk between the TRAF6 and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.