Chakravarti Lab

Research focus

NIH R01 · 2024

From GWAS loci to blood pressure genes, variants & mechanisms - Renewal

Defects in systolic (S) and diastolic (D) blood pressure (BP) regulation underlie clinical hypertension and its subsequent target organ damage when unrecognized and untreated. Over the past 15 years, we have been major contributors to the genomic analyses of BP enabling dissection of inter-individual SBP and DBP variation, through this FEHGAS research program in collaboration with national/international consortia. While the major approach has been to further expand GWAS, in this renewal (FEHGAS4), we introduce an alternative novel program of using genome-cum-epigenome screens to quantify the contributions of each tissue and cell type to causal BP variation through their transcription…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.