NIH R01 · 2025
Determining hepatocyte-specific mechanisms by which Ube4A regulates NAFLD/NASH
Project summary Obesity is a major risk factor for NAFLD/NASH. In obesity, energy accumulation causes metabolic dysfunction and endoplasmic reticulum (ER) and oxidative stress, leading to tissue inflammation and injury, which are hallmarks of NASH. The DNA damage response and unfolded protein response are vital to maintain the integrity of cellular genome and proteome. The ER maintains proteostasis via ER-associated protein degradation and unfolded protein response. Metabolic dysfunction alters ER-associated protein degradation and unfolded protein response, leading to ER stress, caspase activation and cell death. Moreover, increased oxidative stress enhances DNA damage-induced cell death.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.