NIH R01 · 2024
Molecular mechanisms underlying vocal communication
Project Summary The molecular pathways underlying cognition and vocal communication remain largely unknown. The genes and mechanisms governing these processes are disrupted in many neurodevelopmental disorders, including intellectual disability and autism spectrum disorder. The long-term goal of our laboratory is to study the normal function of genes disrupted in disorders with deficits in cognition, communication, and social behavior, to gain mechanistic understanding that can be leveraged for treatment opportunities. Mutations in the gene encoding the ubiquitin ligase UBE3B have been identified in patients with intellectual disability and lack of speech. The specific mechanism(s) that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.