NIH R01 · 2025
An Image-Guided Microrobotic Drug Delivery Method for Preventive Vascular Interventions
PROJECT SUMMARY/ ABSTRACT End-stage kidney disease (ESKD) affects over 800,000 Americans and 4 million people worldwide, with 60% of patients relying on hemodialysis via arteriovenous fistulas (AVF). Despite diligent monitoring, over 30% of AVFs develop neointimal hyperplasia (IH), leading to venous stenosis (VS) and thrombosis, causing loss of patency as early as six weeks post-creation. The first-line treatment for restoring AVF patency after VS is percutaneous transluminal angioplasty (PTA). However, the efficacy of PTA diminishes with each procedure, as repeated injury to the AVF vessel initiates an injury-healing cycle that exacerbates IH and accelerates VS. These repeated…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.