NIH R01 · 2025
PROJECT SUMMARY Among the six percent of active ethanol drinkers who develop an alcohol use disorder (AUD), there is great variability in etiology and relapse rates. Early and accurate identification of individuals at risk of developing an AUD would facilitate effective deployment of personalized interventions. Recent evidence demonstrates that individuals with low cognitive flexibility and a predisposition towards habitual behaviors are at an increased risk for future heavy drinking. However, the underlying molecular mechanisms driving these differences in cognition and the accompanying higher risk for drinking remain unknown. Growing evidence suggests that an epigenetic signature, either…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.