NIH R01 · 2025
PROJECT SUMMARY Acute Respiratory distress syndrome (ARDS) is a life-threatening condition caused by widespread pulmonary inflammation leading to lung injury. ARDS has a mortality that can be higher than 40% and is the main cause of death from COVID-19. Although necessary to support life, mechanical ventilation worsens ARDS. While computed tomography (CT) is capable of identifying characteristic abnormal airspace mechanics, the pulmonary circulation is also altered in ARDS, with profound dysregulation of lung perfusion resulting in regional elevations of blood flow and volume. Such misdistribution may significantly impact the trajectory of lung injury. In animal studies, ventilated lungs…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.