NIH R01 · 2025
Imaging the Respiratory Effects of Truncal Adiposity in Acute Hypoxemic Respiratory Failure
PROJECT SUMMARY Obesity affects more than 40% of the United States population and is a major risk factor for acute hypoxemic respiratory failure (AHRF). AHRF patients with obesity have more ventilator-related morbidity and may be less responsive to standard respiratory care treatments, such as prone position and positive end expiratory pressure (PEEP) titration, compared to patients of normal body weight. Excess truncal adiposity in obesity elevates intrathoracic pressure (ITP) and compresses lung tissue. Our prior research has shown that obesity also modifies ventilator-induced lung stretch. In addition to the mass of adiposity, published and preliminary data suggest that the distribution…
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