NIH R01 · 2024
Role of the stromal microenvironment in B-cell lymphoma progression and immune escape
PROJECT SUMMARY/ABSTRACT This project focus in the biology of diffuse large B-cell lymphoma (DLBCL) that are common aggressive malignancies with a curability rate of 65% despite intensive chemoimmunotherapy. DLBCLs display an array of genetic alterations, that define molecular subtypes, and strong dependence on the microenvironment for survival. We hypothesize that reprogramming of the stromal microenvironment is critical for the oncogenicity of hallmark mutations that mediate lymphoma progression and immune evasion. We propose to elucidate the roles of the cancer-associated fibroblasts (CAF) and extracellular matrix (ECM) components of the lymphoma microenvironment to identify therapeutic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.