Celli Lab

Research focus

NIH R01 · 2024

Remodeling of intracellular membrane traffic by Brucella effectors

Project Summary Most bacterial diseases of public health significance are caused by pathogens with an intracellular lifecycle that is integral to their virulence. These microorganisms exploit a variety of host cell functions to ensure their intracellular survival and proliferation, via delivery of effector proteins or toxins that modulate specific host processes, including intracellular membrane transport by vacuolar pathogens. The Golgi apparatus plays a central role in the host secretory traffic of cellular components and is targeted by many bacteria for the purpose of vacuole biogenesis and maintenance or intracellular nutrient acquisition. Little is known, however, about the bacterial…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.