Celi Lab

Research focus

NIH R01 · 2024

New Approaches for the treatment of Hypothyroidism

Project Summary This submission is in response to PAS-23-086, Small R01s for Clinical Trials Targeting Diseases within the Mission of NIDDK. Hypothyroidism is a common condition associated with excess of cardiovascular risk and poor quality of life which are not completely abrogated by treatment with levothyroxine (synthetic T4, LT4), potentially because of the inability to compensate for the loss of T3 secreted by the thyroid gland. Experimental data in animal models indicate that only combination LT4 and liothyronine (synthetic T3, LT3) can restore normal concentrations of thyroid hormones across the tissues target of the hormonal action. Clinical trials based on LT4/LT3 combination…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.