NIH R01 · 2024
Interrogating the role of LRP1 subdomains in neural stem cell function
Project Summary/Abstract This is an administrative supplement to support the career development and training of a deserving underrepresented applicant, Damian Lozano, as he completes his dissertation research. The parent R01 involves studying mechanisms which contribute to outcomes after ischemic stroke, the leading cause of long- term disability in the U.S. Neural stem cells (NSCs) have demonstrated therapeutic benefit in stroke recovery, however mechanisms are still being elucidated. Our data show NSC function is influenced by low-density lipoprotein receptor-related protein (LRP1), a multifunctional modulator of cell signaling. We discovered that in NSCs, LRP1 enables NSC migration to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.