NIH R01 · 2025
Vesicular trafficking mechanisms regulating granulocyte function
Project Summary: Intracellular vesicular transport is essential for all aspects of neutrophil physiology and defects in this mechanism leads to disease in humans. In neutrophils, vesicular trafficking is associated with the processes of exocytosis, phagocytosis, signaling and NETs production; however, the molecular mechanisms that regulate mobilization of the different neutrophil secretory organelles require further elucidation. We have identified several key regulators of neutrophil granule trafficking, including the small GTPase Rab27a and its effectors JFC1 and Munc13-4. We have now identified WASH as a neutrophil factor that regulates cytoskeleton remodeling, vesicular trafficking and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.