Catteruccia Lab

Research focus

NIH R01 · 2025

From bench to bednet: Developing novel mitochondrial inhibitors for killing Plasmodium in the malaria mosquito

Project Summary Malaria transmission occurs through the bite of Plasmodium-infected mosquitoes of the genus Anopheles, and in much of sub-Saharan Africa, transmission of the deadliest Plasmodium falciparum parasites is mediated by the sibling mosquito species Anopheles gambiae and An. coluzzii. The best method available to prevent malaria infection is through long-lasting insecticide impregnated mosquito bed nets (LLINs). Distribution of LLINs has had a massive impact on the number of malaria cases, particularly in sub-Saharan Africa, with epidemiological modelling predicting that between 2000 and 2015 LLINs were responsible for as much as 68% of the observed reduction in malaria cases in…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.