NIH R01 · 2024
SUMMARY HIV infected patients have twice the risk of cardiovascular disease relative to the general population. The main drivers of cardiovascular events in patients with HIV infection are associated with chronic immune activation, systemic inflammation and endothelial dysfunction. The molecular pathways linking HIV-driven chronic T immune activation, vascular inflammation and increased risk of cardiovascular disease are largely unknown. In this proposal, we will investigate the underlying mechanisms driving vascular inflammation/damage during HIV infection by focusing in the function of angiogenic CD8 T cells (CD8 Tangs). Under physiological conditions, Tang cells play a role in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.