NIH R01 · 2024
Pediatrichigh-grade gliomas (pHGGs) are one of the most aggressive forms of brain cancer, with a median survival (MS) of ~18 months 1,2. The current standard of care for pHGG, consisting of tumor resection followed by radiation and chemotherapy, elicits only a modest increase in MS 1-4. The main reasons for the limited therapeutic outcomes are tumor recurrence, caused by the infiltrative nature of pHGG, and the development of an immune-suppressive tumor microenvironment (TME). One of the main subtypes of hemispherical pHGG encodes for G34R/V substitutions in the histone H3F3A 4, along with ATRX and TP53 inactivating mutations. The investigation of the molecular pathways which play a role in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.