NIH R01 · 2024
Polymerase epsilon-based mouse and derived organoid models of intestinal cancer
PROJECT SUMMARY/ABSTRACT Intestinal cancer is the 3rd most common malignancy and cause of cancer-related deaths in both men and women. Unfortunately, recent advances in our understanding of the underlying intestinal biology and cancer- related pathways have not translated to significantly improved patient outcomes. While numerous animal models of intestinal cancer have been developed, mostly based on misregulation of the β-catenin pathway, some key features of human cancers (particularly tumor mutational burden) now known to be critical for tumor progression and therapy response, have not been adequately modelled or investigated in animal models of intestinal cancer. More recently, genome…
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