NIH R01 · 2025
Trpv4 regulation of lymphatic vascular function: Implications in metabolic syndrome
PROJECT SUMMARY A major function of the lymphatic system is fluid transport, which is critical for fluid homeostasis, lipid transport and metabolism, and the transport of immune cells and pro-inflammatory molecules. Lymphatic vessels contract spontaneously to pump fluid, while intraluminal one-way valves ensure net forward flow. Our group and others have shown that obesity and metabolic syndrome can cause different forms of lymphatic vascular dysfunction. In fact, this connection is a dysfunction- and disease-promoting feedback loop, as lymphatic dysfunction also contributes to obesity. This suggests pharmacological improvement of lymphatic function as a potential therapeutic alternative in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.