NIH R01 · 2024
Presynaptic forms of long-term plasticity in the CNS
The ability of synapses to change their functional and structural properties in response to activity, called synaptic plasticity, is essential for experience-dependent adjustments of brain function. A widely expressed mechanism of synaptic plasticity in the CNS involves long-term changes in neurotransmitter release. Dysregulation of presynaptic plasticity has been implicated in the pathophysiology of a number of neuropsychiatric conditions, including cognitive disorders, autism spectrum disorders (ASD), intellectual developmental disabilities, mood disorders, schizophrenia, epilepsy and drug addiction. Despite significant advancements in the molecular basis of neurotransmission, exactly how…
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