Castillo Lab

University of Texas at Austin

RADIATION-DIAGNOSTIC/ONCOLOGY

Austin · United States

NIH-funded
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NIH R01 · 2025

CT-Derived Functional Imaging for Predicting Disease Progression in COPD

PROJECT SUMMARY Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States, imposing a significant economic burden due to its high morbidity and mortality. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria is a universally accepted disease severity staging score. However, GOLD score is not a strong predictor for mortality or progression risk at early or pre-disease stages. Early intervention is crucial for slowing COPD progression and improving quality of life. Therefore, there is a need to develop robust, quantitative metrics for characterizing disease state and progression risk. Existing quantitative computer tomography…

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