NIH R01 · 2024
Genetic dissection of ciliary ARL13B in kidney cystogenesis
The objective of this proposal is to refine the understanding of the signaling mechanism(s) within the primary cilium in relation to polycystic kidney disease (PKD). Renal cysts interfere with kidney function and lead to major, long-term health complications. PKD and its related health complications result in a $7 billion per year economic burden in the United States so identifying molecular targets for treatment is a pressing unmet clinical need. Cilia, the slender protrusions on all renal cells, play key roles in cell signaling and cystogenesis but the details and underlying mechanism are ill-defined. Autosomal dominant polycystic kidney disease (ADPKD) is primarily due to mutations in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.