Caspary Lab

Southern Illinois University Sch of Med

PHARMACOLOGY

Springfield · United States

NIH-funded
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NIH R01 · 2024

Coding in Auditory Neurons: Effects of Amino Acids

PROJECT SUMMARY Age-related hearing loss (ARHL) is a complex disorder affecting between 50-70% of the United States population aged 65 or older. In public settings, seniors frequently have great difficulty understanding speech, which can lead to withdrawal from social activities, depression and cognitive decline. All individuals and especially the elderly can maintain speech understanding in difficult listening conditions by engaging attentional, cognitive and mnemonic (top-down) resources to help disambiguate speech from a degraded ascending acoustic code. Understanding the impact of aging on circuits that maintain speech understanding and the pharmacology of cholinergic attentional…

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