NIH R01 · 2025
The role for ER associated degradation (ERAD) in T cell homeostasis and memory
PROJECT SUMMARY CD8+ T cells are critical to eradicate viral infections and tumors, as well as providing long-lasting protection; however, not all immune responses elicit functional and durable immune responses leading to loss of protection against intracellular pathogens and cancer. Effective T cell immunity requires tight control to maintain the appropriate equilibrium between cellular quiescence, activation and cell death. Elegant work has been done to elucidate the transcriptional, epigenetic and metabolic networks that regulate T cells. In contrast, much less is known about how cellular protein homeostasis (proteostasis) regulates CD8+ T cell fate. Proteostasis is maintained primarily…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.