NIH R01 · 2025
Long distance regressive signaling underlies sculpting of the nervous system during development.
PROJECT SUMMARY Neurodevelopmental events occurring after axons innervate their targets can be categorized as either progressive (e.g., cell survival, axon stabilization, promotion of synapse formation) or regressive (e.g., cell death, axon degeneration, synapse restriction). While the molecular and cellular basis of long-distance progressive signaling is relatively well-characterized, the understanding of long-distance regressive signaling remains limited. Many target-derived regressive cues, such as trophic factor deprivation (TFD), repulsive axon guidance cues, neurotrophin and pro-neurotrophin binding, converge on the p75 neurotrophin receptor (p75NTR). Studying this single receptor…
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