NIH R01 · 2025
Regulation of disease progression by ER stress
There is no current curative therapy for asbestos-induced fibrosis. Recruited monocyte-derived macrophages (MDMs)play a critical role in the pathogenesis of asbestos-induced disease progression. The activation of MDMs is dependent on their metabolic profile. Metabolic reprogramming is a key feature in macrophage activation; however, the regulation of metabolic reprogramming of macrophages in asbestos-induce fibrosis progression is poorly understood. Other than causing an alternative phenotype in certain macrophages, little is known about ER stress and UPR in lung macrophages. The effect of ER stress and UPR on metabolic reprogramming in lung fibrosis has not been investigated in any cell…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.