NIH R01 · 2025
Curing chronic Toxoplasma infection with novel and potent protease inhibitors
PROJECT SUMMARY Zero effective options exist for treating individuals who are chronically infected with the protozoan parasite Toxoplasma gondii (Tg) as a source of reactivated toxoplasmosis. Reactivated Tg infection in the retina is a leading cause of infectious posterior uveitis, impairing the vision of approximately 3,600 Americans annually. Some individuals experience multiple episodes of reactivated ocular toxoplasmosis, with each bout further eroding their vision. Eliminating Tg tissue cysts could preclude reactivated ocular toxoplasmosis and preserve the vision of at-risk individuals. We have identified a Tg lysosomal protease (TgCPL) that is critical for chronic Tg infection,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.