NIH R01 · 2024
Mitigation of Cerebral Infarct Growth in Acute Ischemic Stroke Using a Novel Blood Substitute
Project Summary/Abstract The aging of the population in industrialized nations is increasing the number of ischemic strokes that present in the emergency rooms of hospitals. In the ischemic stroke neurons die rapidly (estimated at 1 million neurons per minute) prompting the need for rapid triage and treatment to open the blocked blood vessel. We have previously established that the exact rate at which neurons die and size of the infarction grows is highly variable among patients and depends strongly on the degree of leptomeningeal arterial collateralization. The goal of this proposal is to test a new biopharmaceutical agent (Sanguinate®) that is designed to boost the collateralization in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.