NIH R01 · 2025
Type I Interferon induction of neuroinflammation mediates neuropsychiatric lupus
ABSTRACT: In addition to peripheral symptoms such as skin and kidney disease, many Lupus patients (60-80%) also develop psychiatric symptoms referred to as neuropsychiatric lupus (NPSLE). Recently, we reported an interferon stimulated gene (ISG) signature in the CNS in a strain of lupus mice (Sle1 yaa) that correlated with a behavior phenotype. Using a novel spacial transcriptomic approach (MERFISH), we found discrete patches of cells in the brain and spinal cord that express elevated levels of ISG. The novel finding not only demonstrates IFN- I triggering of neuroinflammation in the CNS but suggests cell activation by IFN-1 is not random but spacially regulated. The discrete patches of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.