NIH R01 · 2024
Chemical Tools for Probing Cysteine Sulfenation and Sulfination Redox Biology
PROJECT SUMMARY Post-translational changes in the redox state of cysteine residues can rapidly and reversibly alter protein function, modulating biological processes and drug pharmacology. During the last funding period, our lab reported several innovations in organosulfur chemistry, small-molecule tools, and computational methods for proteomic analysis that dramatically improved selectivity, cellular application, and site-specific quantitation of the cysteine redoxome (J. Am. Chem. Soc., 2017; Nat. Chem. Biol., 2018; Nat. Chem., 2021; Nat. Comm., 2022). Application of these chemoproteomic methods has contributed to meaningful discovery of new paradigms in redox biology (Nat. Cell Biol.,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.