NIH R01 · 2025
IgSF protein interactions drive specificity in circuit wiring and synaptic elaboration
Project Summary In this application, we examine the molecular mechanisms that instruct neural wiring and axon terminal elaboration. We focus on the Drosophila neuromuscular system due to its invariant connectivity, limited synaptic partners, and accessibility. Given that this ‘simple’ circuit has been studied for over four decades, it is somewhat surprising that fundamental questions still exist as to how motor neurons choose their appropriate muscle targets and how each motor neuron develops a unique, yet stereotyped, axon terminal structure that underlies synaptic function. Conceptually, both of these developmental processes rely on specificity cues to guide synaptic partner matching…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.