NIH R01 · 2025
Magnetic Resonance Imaging of Outbred Rats with Variable Vulnerability to Compulsive Alcohol Use
PROJECT SUMMARY/ABSTRACT Advancements in neuroscience, including magnetic resonance imaging (MRI), have significantly improved our understanding of alcohol use disorder (AUD) and brain function, yet due to the heterogeneity in the disorder and complexity of the brain, controlled comprehensive approaches in diverse populations are a necessity to characterize individual variability. Here, longitudinal multi-parametric MRI will be employed to assess brain features associated with AUD in a large cohort (N=100, 50% female) of genetically diverse (heterogeneous stock) rats sourced from the NIAAA-funded Rat Alcohol Biobank (1R01AA030048, 5R01AA029688), which provides rats with fully characterized…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.