NIH R01 · 2025
Molecular mechanisms of post-transplant recurrent alcoholic liver disease
PROJECT SUMMARY This proposal outlines a plan to investigate the role of ceramide synthase 6 in alcohol-induced lipid droplet biogenesis and as a potential diagnostic biomarker of pre- and post-liver transplant alcoholic liver disease (ALD) recurrence. The research will use novel in vitro and in vivo model systems to investigate the hypothesis that the ceramide synthetic enzyme ceramide synthase 6 (CerS6) regulates alcohol-induced lipid droplet biogenesis through the transcriptional regulation of the lipid droplet protein, Perilipin 2 (PLIN2). Furthermore, this proposal will investigate the association between CerS6 upregulation in alcoholic steatosis and its use as an early biomarker of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.