NIH R01 · 2025
Small-molecule probes for augmenting D5 receptor signaling
Project Summary Cognitive impairment is a core feature of many neuropsychiatric disorders that directly correlates with functional outcome for patients. Current treatment options are inadequate and there is a need for novel therapeutic strategies. The dopamine D1-like receptor family (D1 and D5 receptors) has been proposed as a potential target for improving cognitive function. Clinical studies with D1/D5 full agonists have shown promising efficacy, but these compounds suffer from significant drawbacks related to adverse effect profiles. The lack of selective ligands as well as considerable spatial overlap between the D1 and D5 receptors have made it difficult to determine which receptor is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.