Carpino Lab

Research focus

NIH R01 · 2025

Optimizing anti-microbial immunity by targeting Sts-1

Project Summary Recent studies have established two homologous phosphatases, Sts-1 and -2, as negative regulators of immune signaling pathways. Interestingly, mice lacking Sts expression (Sts-/-) are profoundly resistant to infection by a number of virulent microbial pathogens, including Candida albicans, Staphylococcus aureus, and Francisella tularensis. Resistance is associated with rapid pathogen clearance, reduced inflammation, and increased survival. The overall goal of this project is to develop new therapeutic strategies that promote enhanced anti- microbial immune responses. The hypothesis to be tested is that drug-mediated inhibition of Sts phosphatase activity will recapitulate…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.