NIH R01 · 2024
Determining the conserved molecular mechanisms contributing to inflammation during Sepsis
Project Summary Worldwide it is estimated that over 6 million people die each year as a result of sepsis. There are few clinical treatment options for patients, therefore, it is critical to determine the molecular mechanisms that occur during sepsis in order to identity new targets for therapeutic intervention. Here we identify the long noncoding RNA, GAPLINC, as a conserved gene between human and mice that is highly expressed in macrophages. We show that GAPLINC knockouts are resistant to LPS induced septic shock. The overall aim of this proposal is to determine how GAPLINC contributes to the immune response that leads to septic shock. In Aim 1 we will utilize our genetic mouse models to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.