NIH R01 · 2025
We have only a basic understanding of how variation in human T cell responses elicited after Mycobacterium tuberculosis (Mtb) exposure and infection are linked to clinical outcomes. Emerging data in animal models and humans demonstrate that direct T cell recognition of Mtb-infected macrophages, the niche cell for Mtb infection, is central to a protective response. The premise of this proposal is that insight into which antigens are processed and presented by Mtb-infected macrophages, together with the composition, distribution, and kinetics of the T cell repertoire that target these antigens is vital to developing vaccines that prevent active tuberculosis (TB). In Uganda, our original study…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.