NIH R01 · 2025
ABSTRACT. Metastasis is the primary cause of breast cancer deaths and many therapies for metastatic patients are more effective when immune cells are within the tumor. However, metastatic breast tumors have less immune cells compared to primary tumors, especially CD8+ T cells, whose absence is a predictor for worse outcomes. This creates a problem wherein tumors exclude antitumor immune cells that would make therapies more effective. A gap in knowledge is the regulation of immune cell infiltration to metastatic tumors, which could be harnessed to increase immune trafficking to make therapies more effective. Our work identified that heat shock factor 1 (HSF1) can suppress the presence of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.