NIH R01 · 2024
The role of pericytes in scar formation following stroke and myocardial infarction
Stroke and myocardial infarction (MI) are ischemic diseases that are leading causes of mortality and morbidity. Due to the limited regenerative capacity of the brain and the heart, injury leads to irreversible loss of neurons and cardiomyocytes, with subsequent scar formation. The process of scar formation is highlighted by excess deposition of extracellular matrix proteins which blocks tissue repair and prevents functional recovery in the brain and the heart. In the brain, recent evidence indicates that the traditional concepts of astrocytes forming scar may be incorrect. In the heart, there may be a key role for other mesenchymal cells in scar formation in addition to cardiac fibroblasts.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.