NIH R01 · 2024
Synaptic Vesicular Alterations after Traumatic Brain Injury
Abstract Enduring cognitive, somatic, and emotional impairments, including difficulties with memory, attention, and learning, are reported as major contributors to reduced quality of life from patients living with a traumatic brain injury (TBI). Previous preclinical studies highlight the contribution of altered neurotransmission and synaptic dysfunction in the development of cognitive impairments after a TBI. We recently identified a novel synaptic pathology in which the density and distribution of the intrasynaptic vesicular pool is drastically reduced after an experimental TBI, with direct implications for impaired neurotransmission and cognition. A similar finding of altered vesicle…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.