NIH R01 · 2024
Cfp1 Action in Cartilage Development
Endochondral ossification is a process by which mesenchymal progenitor cells (MPCs) differentiate into cartilage prior to forming bone. Perturbations in their capacity to differentiate leads to skeletal anomalies. Therefore, deciphering the molecular mechanisms controlling these cells is crucial for both understanding the causes of skeletal diseases as well as developing new therapeutic approaches to restore the skeleton. While transcription factors and signaling molecules have been linked to cartilage development, less is known about the upstream mechanisms that initiate the process. Recent data from mice and humans implicate epigenetic regulatory factors as critical modulators of MPC…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.