NIH R01 · 2025
Roles of nuleus accumbens CREB and Kappa function in depression
SUMMARY This application is for competitive renewal of a grant that over its 20-year course has elucidated the ways in which the function of the transcription factor CREB and kappa-opioid receptor (KOR) systems within the nucleus accumbens (NAc) are changed by experience, including stress exposure, and how alterations in their function affect behavior. We have shown that (a) stress upregulates NAc CREB and KOR signaling, (b) these effects are sufficient to produce characteristic features of mood and anxiety disorders, and (c) disruption of CREB or blockade of KORs produces antidepressant- and anxiolytic-like effects. Recently we have also shown a role for these systems in sleep and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.