NIH R01 · 2025
Bitter taste receptors in oral cancer tumor-associated macrophages
PROJECT SUMMARY Oral squamous cell carcinomas (OSCCs) are associated with poor prognosis and a 5-year mortality rate of approximately 50%. These tumors are influenced by the cancer cells, tumor microenvironment, and host immune system, with tumor-associated macrophages (TAMs) playing a pivotal role in shaping the immune response and clinical outcomes. Macrophages exhibit diverse activation states, broadly categorized into pro- inflammatory (M1) and anti-inflammatory (M2) subtypes, impacting tumor progression and metastasis. Targeting macrophage pathways has emerged as a promising therapeutic approach for solid tumors, including OSCC, but the underlying signaling pathways that mediate cancer…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.